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李小龙, 博士

高级研究员

哈佛大学/麻省理工学院/麻省总院附属Ragon研究所

Dana-Farber癌症研究所

哈佛大学医学院

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地址: 400 Technology Square, Cambridge, MA 02139

邮箱: xiaolong@crystal.harvard.edu

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简介

李小龙，生物化学、结构生物学博士，2011年入中国科学技术大学硕-博连读; 2012年7月至2014年11月于北京大学联合培养；2014年12月至2016年6月获得美国哈佛大学医学院资助，赴Dana-Farber癌症研究所进行博士研究生联合培养；2016年获理学博士学位，同年于哈佛医学院附属Dana-Faber癌症研究所任研究员。现就职于哈佛/麻省理工学院/麻省总院附属Ragon研究所，任高级研究员。 长期从事生物化学、分子生物学、生物物理、传染性疾病、免疫学及结构生物学等交叉学科研究。研究对象涉及T细胞膜表面受体、抗体、神经元发育引导分子、磷酸激酶等结构与功能研究。师从滕脉坤教授（中国科学技术大学）、王家槐教授（Dana-Farber）、Ellis Reinherz教授（Dana-Farber） 以及Bruce Walker教授（Ragon Institute）, 在T细胞发育，以及体液免疫与细胞免疫介导的适应免疫抵抗感染性疾病（如HIV/AIDS）的分子机制研究方面有长期的研究经验。

最近发表文章

  1. Li X#, Singh, N.K., Collins, D.R. et al. Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide. Nat Commun 14, 2929 (2023). https://doi.org/10.1038/s41467-023-38573-8 (# correspondence)

  2. Tan K., Chen J., Kaku Y., Wang Y., Donius L., Khan R.A., Li X., Richter H., Seaman M.S., Walz T., Hwang W., Reinherz E.L., Kim M., Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility, Nat Commun 14 (1), 7218 (2023)

  3. Jiang C., Liu J., He S., Xu W., Huang R., Pan W., Li X., Dai X., Guo J., Zhang T, Inuzuka H., Wang P., Asara J.M., Xiao J., Wei W. PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2. Cell Metabolism. 35(12), P2183-2199.E7 (2023)

  4. Tano-Menka R., Singh N, Muzhingi I, Li X, Mandanas M., Kaseke C., Zhang A., Ogunshola F, Vecchiarello L, Piechocka-Trocha, A, Bashirova A., Birnbaum M., Carrington M, Walker B.D., Gaiha G.D. Residues in HLA class I that Account for Variation of the HIV Host Response Distinctly Modulate Interactions with TCR and KIRs. Research Square; 2022. DOI: 10.21203/rs.3.rs-2105002/v1.

  5. Zhang A, Piechocka Trocha A, Li X#, Walker BD#, A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the Escherichia Coli Expression System. Cells 2022, 11, 312. https://doi.org/10.3390/cells11030312 (# correspondence）

  6. Chen A, Zhao W, Li X, Sun G, Ma Z, Peng L, Shi Z, Li X, Yan J. Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme. Frontiers in Immunology, 2022, 13.

  7. Li X*, Mizsei R*, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte β-selection. Science. 2021 Jan 181-185. （* contribute equally）

  8. Mizsei R, Li X, Chen WN, Szabo M, Wagner G, Wang JH, Reinherz EL, Mallis RJ. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021, RA120. 016906.

  9. Xu S, Liu Y, Li X, Liu Y, Meijers R, Zhang Y, Wang JH. The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction. Cell Discov. 2018 Feb 20;4:8 

  10. Li X, Lamothe PA, Walker BD, Wang JH. Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation. Cell Mol Immunol. 2017 Jul;14(7):631-634.

  11. Li X, Structural Study of Human Lymphocyte Antigen B*5801 and Structural Study of Complex of Phosphoglycerate Kinase with Terazosin, University of Science and Technology of China (2016)

  12. Li X, Lamothe PA, Ng R, Xu S, Teng M, Walker BD, Wang JH. Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection. Protein Cell. 2016 Oct;7(10):761-765.

  13. Chen X*, Zhao C*, Li X*, Wang T*, Li Y, Cao C, Ding Y, Dong M, Finci L, Wang JH, Li X, Liu L. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat Chem Biol. 2015 Jan;11(1):19-25. (* contribute equally)

  14. Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ. Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1517-22. 

  15. Li X, Teng M, Reinherz EL, Wang JH. Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβTCR Recognition during T Lineage Subset Commitment. Front Immunol. 2013 Nov 22;4:383. 

  16. Li X, Sun J, Pan B, Zhu L, Huang X, Zhang B.  ΔSACE_0065，ΔSACE_2559 and ΔSACE_2565 genes mutation in Saccharopolyspora erythraea and their effect on spore differentiation. Military Medical Sciences. 2011 Dec; 35(12): 913-916.

​学术会议报告

受邀报告

  1. Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked viral peptide, Institut Pasteur Seminar, Institut Pasteur (France), Nov. 8th, 2022, Host: Prof. Félix A. Rey (FAS, AE)      

  2. New Insights into the Roles of Pre-TCR and Co-receptors in T Cell Development, Wellcome Centre for Human Genetics Seminar, University of Oxford (UK), Nov. 2nd, 2022, Host: Prof. E. Yvonne Jones (FRS, FMedSci)

  3. Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked viral peptide, Fine Seminar, University of Edinburgh (UK), Oct. 22nd, 2022, Host: Prof. Jim Kaufman (Chair of Immunology)

  4. Molecular basis of a non-protective HLA-mediated immune response against HIV-1 infection, IPI Seminar, The Institute for Protein Innovation (Boston, USA), Apr. 23rd, 2021. Host: Dr. Rob Meijers

  5. Pre-T cell receptors topologically sample self-ligands during thymocyte β-selection, Brain Lunch Seminar, Dana-Farber Cancer Institute/PGA (Boston, USA), Apr. 16th, 2021. Host: President Han Dong

 

学术会议

  1. 18th International Congress of Immunology, IUIS2023, Molecular basis of differential HLA-restricted immune recognition of a highly networked HIV viral peptide. Cape Town, Dec 29 2023

  2. 35th Annual Symposium of the Protein Society: Crystallographically resolved preTCR-pMHC complexes reveal the structural basis of β selection during early T cell development. Virtual Meeting (07/12/2021)

  3. International Young Scholar Forum of Shanghai Jiao Tong University School of Medicine:  
    Structural Investigation in Adaptive Immunity (06/18/2021)

  4. Harvard Medical School/Department of Microbiology – Monday Talk: Molecular basis of differential HLA-restricted immune recognition of a highly networked viral peptide (03/15/2021)

  5. Ragon-NEIDL Symposium: Structural investigation into CD8+ T cell control of HIV-1, Boston, Massachusetts, USA. (2020) 

  6. 25th Annual Harvard Structural Biology Retreat: Structural basis of T cell immune escape caused by a single mutation in HIV-1 Gag epitopes, QW9 and TW10, Boston, Massachusetts, USA. (2019)

  7. NIH Structural Biology Meeting Related to HIV/AIDS: A novel Mode of Peptide Presentation of Major Histocompatibility Complex Class I, Bethesda, Maryland, USA. (2018)

  8. 32nd Annual Symposium of the Protein Society: A novel Mode of Peptide Presentation of Major Histocompatibility Complex Class I, Boston, Massachusetts, USA (2018)

  9. Harvard Medical School/Department of Immunology–Monday Talk: Structural Analysis of Protective and  Non-Protective HLA Alleles in HIV Infection, Boston, Massachusetts, USA (2017/11/27)

  10. 23rd Annual Harvard Structural Biology Retreat: Crystal structure of HLA-B*5801 with an HIV Gag epitope TW10 reveals a novel mode of peptide presentation. Boston, Massachusetts, USA. (2017)

  11. 22nd Annual Harvard Structural Biology Retreat: Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Boston, Massachusetts, USA. (2016)

  12. 21st Annual Harvard Structural Biology Retreat: Strict major histocompatibility complex molecule class-specific binding by co-receptors enforces MHC-restricted αβ TCR recognition during T lineage subset commitment. Boston, Massachusetts, USA. (2015)

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